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KMID : 0858219990030040308
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Intravenous Anesthesia
1999 Volume.3 No. 4 p.308 ~ p.313
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Effect of Intramuscular Lidocaine before Induction on Hypnotic Requirement of Intravenous Propofol
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Kim Keon-Sik
Kang Hwa-Ja
Choi Young-Kyu
Lee Doo-Ik
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Abstract
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Background : When a dose of local anesthetic is injected to provide pain relief for a surgical procedure, but is either insufficient and ineffective, the anesthesiologist should consider the use of drugs for general anesthesia. There is a growing interest in the possible interactions of local and regional anesthesia with drugs used for general anesthesia. We have compared the hypnotic requirements for intravenous propofol when intramuscular lidocaine was injected before induction of anesthesia.
Methods : Seventy five women (ASA Ⅰ, Ⅱ) undergoing gynecological surgery were allocated randomly to one of five groups of 15 patients to receive propofol intravenously combined with intramuscular 4% lidocaine (0.5, 1.0, 1.5 and 2.0 ㎎/㎏) or saline 10 min before induction of anesthesia, respectively. Propofol was administered in bolus doses of
0.2 ㎎/㎏ every 30 sec until loss of response to verbal command.
Results : The mean dose of propofol for hypnosis in control group (saline) was 1.72± 0.17 ㎎/㎏. 0.5 (group 2) and 1.0 ㎎/㎏ (group 3) of lidocaine did not reduce significantly the hypnotic dose of propofol but 1.5 (group 4) and 2.0 ㎎/㎏ (group 5) of lidocaine reduced significantly.
Conclusion : We conclude that if lidocaine is injected into soft tissue before induction of anesthesia by propofol, the intravenous dose of propofol should be modified because lidocaine enhances the hypnotic effect of propofol in a dose dependent manner.
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KEYWORD
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Anesthetics intravenous, propofol, Anesthetics local, lidocaine, Interactions, drug,
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